Mercury poisoning afflicted mirror-makers and hat-makers for generations. However, this did not deter the pioneers of photography from using the dangerous metal in their early experiments. In 1839, Frenchman Louis Daguerre perfected a process that used mercury to bind a photographic image to a silver-coated copper plate. Millions of daguerreotypes like the examples seen here revolutionized portraiture throughout Europe and America. They were made, however, at the expense of many photographers who became ill or died from mercury poisoning.